Humalog (Lispro)
Based on Humalog (Insulin Lipspro) data from: https://link.springer.com/article/10.1007/s40262-020-00903-0/figures/2
Source:
Linnebjerg, H., Zhang, Q., LaBell, E. et al. Pharmacokinetics and Glucodynamics of Ultra Rapid Lispro (URLi) versus Humalog® (Lispro) in Younger Adults and Elderly Patients with Type 1 Diabetes Mellitus: A Randomised Controlled Trial. Clin Pharmacokinet 59, 1589–1599 (2020). https://doi.org/10.1007/s40262-020-00903-0
URLi
Based on URli data from: https://link.springer.com/article/10.1007/s40262-020-00903-0/figures/2
Source:
Linnebjerg, H., Zhang, Q., LaBell, E. et al. Pharmacokinetics and Glucodynamics of Ultra Rapid Lispro (URLi) versus Humalog® (Lispro) in Younger Adults and Elderly Patients with Type 1 Diabetes Mellitus: A Randomised Controlled Trial. Clin Pharmacokinet 59, 1589–1599 (2020). https://doi.org/10.1007/s40262-020-00903-0
Based on Human Insulin data from:
https://diabetesjournals.org/view-large/figure/3735433/zdc0100764960001.jpeg
Source:
Becker, R. H., Frick, A. D., Nosek, L., Heinemann, L., & Rave, K. (2007). Dose-response relationship of insulin glulisine in subjects with type 1 diabetes. Diabetes care, 30(10), 2506–2507. https://doi.org/10.2337/dc06-2114
Human Insulin 0.3 U/kg:
Glulisine
Based on Glulisine data from:
https://diabetesjournals.org/view-large/figure/3735433/zdc0100764960001.jpeg
Source:
Becker, R. H., Frick, A. D., Nosek, L., Heinemann, L., & Rave, K. (2007). Dose-response relationship of insulin glulisine in subjects with type 1 diabetes. Diabetes care, 30(10), 2506–2507. https://doi.org/10.2337/dc06-2114
Glulisine 0.3 U/kg
(These IOB curves are naturally dependent on a lot of factors,which could have been taken in to consideration for all types of insulin and the transformation of U/kg to units is not always correct. Also finding a general formula is preferred.)
Insulin Aspart
Data source:
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/112c/7540588/120b30854720/DOM-22-1789-g001.jpg
From:
Heise, T., Linnebjerg, H., Coutant, D., LaBell, E., Zijlstra, E., Kapitza, C., Bue-Valleskey, J., Zhang, Q., Dellva, M. A., & Leohr, J. (2020). Ultra rapid lispro lowers postprandial glucose and more closely matches normal physiological glucose response compared to other rapid insulin analogues: A phase 1 randomized, crossover study. Diabetes, obesity & metabolism, 22(10), 1789–1798. https://doi.org/10.1111/dom.14094